LipidCompass

LipidCompass is a database to help you navigate and explore the lipid structural space and the range of lipid quantities.

At the moment, LipidCompass is in a closed beta testing phase. If you are interested to try it out, please use our Contact Form (Support Category: LipidCompass) to request instructions for access.

Please note that only dataset accessions with public visibility will be displayed below. Accession links will become active, once curation and data import into LipidCompass have been finished.

LipidCompass is operated at two main, regularly synchronized sites:

Institute of Analytical Chemistry, University of Vienna, Austria, operated by the Lipidomics Group (Robert Ahrends)
IBG-5, Forschungszentrum Jülich outstation at Bielefeld University, Germany, operated by the Data Science and Bioinformatics for Mass Spectrometry Group (Nils Hoffmann)

Title	Glycerophospholipid remodeling is critical for orthoflavivirus infection
Contacts	Eva Herker, This email address is being protected from spambots. You need JavaScript enabled to view it. Institute of Virology, Philipps-University Marburg, Marburg, Germany Dominik Schwudke, This email address is being protected from spambots. You need JavaScript enabled to view it. Division of Bioanalytical Chemistry, Research Center Borstel - Leibniz Lung Center, Borstel, Germany German Center for Infection Research, Thematic Translational Unit Tuberculosis, Partner Site Hamburg-Lübeck-Borstel-Riems, Borstel, Germany German Center for Lung Research (DZL), Airway Research Center North (ARCN), Research Center Borstel - Leibniz Lung Center, Borstel, Germany
Publication	Peer reviewed publication: Hehner, J., Schneider, L., Woitalla, A. et al. Glycerophospholipid remodeling is critical for orthoflavivirus infection. Nat Commun 15, 8683 (2024). https://www.nature.com/articles/s41467-024-52979-y Published: 07 October 2024 Preprint: not available
Accession	LCE00000015 (LipidCompass) MTBLS11030: Glycerophospholipid remodeling is critical for orthoflavivirus infection (MetaboLights)
Status	In curation (Links / accessions may not work yet)
Organism	Human hepatoma HuH-7 cell line (BTO:0001950) infected with Zika Virus (NCBITaxon:64320), West Nile Virus (NCBITaxon:11082), Tick-borne Encephalitis Virus (NCBITaxon:11084), Dengue Virus (NCBITaxon:12637), Yellow Fever Virus (NCBITaxon:11089)
Supplementary Material	Manuscript Supplements: Supplementary Table S1 - Lipid quantities after viral infection at different timepoints (322 lipids, 16 classes): 240123_Table_S1.xlsx Supplementary Table S2 - FA composition of membrane and storage lipids species changes following infection for PC, PE, PS, and TAG: 240123_Table_S2.xlsx Lipidomics Reporting Checklist: Lipidomics Reporting Checklist PDF Lipidomics Results: LipidXplorer Positive ion mode analysis settings: 211129_Virus_Eva_Herker-project.lxp LipidXplorer Positive ion mode report (w/ MFQL): 211129_Virus_Eva_Herker_pos-report_screen.html LipidXplorer Positive ion mode analysis (TAG FA Content) settings: 220719_TAG_FAs.lxp LipidXplorer Positive ion mode report (TAG FA Content, w/ MFQL): 211129_Virus_Eva_Herker_pos-report.html LipidXplorer Negative ion mode analysis settings: 211129_Virus_Eva_Herker-project_neg.lxp Cholesterol determination after acetylation positive ion mode report (w/ MFQL): 210820_Virus_EH_Batch1_Batch2_Batch3_Chol-report.html Cholesterol determination after acetylation negative ion mode report (w/ MFQL): 211022_Virus_EH_Batch1_Batch2_Batch3_neg-report.html
Created	December 12th, 2023
Last Updated	February 25th, 2025
Curators	Nils Hoffmann

Title	Global analysis of putative phospholipases in Plasmodium falciparum reveals an essential role of the phosphoinositide- specific phospholipase C in parasite maturation
Contacts	Paul-Christian Burda, This email address is being protected from spambots. You need JavaScript enabled to view it. Centre for Structural Systems Biology, Hamburg, Germany Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany University of Hamburg, Hamburg, Germany Michael J. Blackman, This email address is being protected from spambots. You need JavaScript enabled to view it. Malaria Biochemistry Laboratory, The Francis Crick Institute, London, United Kingdom Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom Tim-Wolf Gilberger, This email address is being protected from spambots. You need JavaScript enabled to view it. Centre for Structural Systems Biology, Hamburg, Germany Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany University of Hamburg, Hamburg, Germany
Publication	Peer reviewed publication: DOI: 10.1128/mbio.01413-23, Parasitology, ASFM, July, 2023 Preprint: DOI: 10.1101/2021.06.28.450158, BioRxive, CSHL, June 24th, 2021
Accession	LCE00000008
Status	In curation
Organism	Plasmodium falsiparium (NCBITaxon:5833), Knockout (NCIT:C22491): PF3D7_1476800, PI-PLC
Supplementary Material	Manuscript Supplements: Supplementary File 1 - Oligonucleotides and other synthetic DNA used in this study: Supplemental File 1.xlsx Supplementary File 2 - Lipid abundances (relative abundances mol% and pmol/million cells) and paired t-test analysis, source data for Figures 4C,D and S7: Supplemental File 2.xlsx Supplementary File 3 - Lipid standards used for quantification, LC Gradient and ESI source conditions: Supplemental File 3.xlsx Lipidomics Results: LipidXplorer Negative Ion Mode report: mzml_neg-report.html LipidXplorer Positive Ion Mode report: mzml_pos-report.html lxPostman Quantified and Processed LipidXplorer Results report: 221014_184847_lxPostman_report_Burda.xlsx
Created	July 7th, 2021
Last Updated	July 4th, 2023
Curators	Nils Hoffmann

LipidCompass

LipidCompass

LCE00000015 - Glycerophospholipid remodeling is critical for orthoflavivirus infection

LCE00000008 - Global analysis of putative phospholipases in Plasmodium falciparum