Welcome to the web portal for Lipidomics Informatics for Life Sciences (LIFS)
Even with lipid content of over 10% in the human body, lipids were not the central scientific focus during the last decade. However, more and more evidence proves that non-genetically determined molecules such as metabolites and lipids play a critical role in cellular regulation. Today, it is evident that lipids are not only crucial for energy homeostasis and as an environmental-cellular barrier but also that they represent a central part of our signal transduction machinery.
Disruptions of the sensitive lipid metabolism are highly correlated with different diseases, including thrombocytopenia, metabolic syndrome, diabetes, obesity, and hyperlipidemia. This is especially true for the latter, which also reach pandemic levels. Therefore, lipid metabolism is becoming an emerging scientific field and is a central part of pharmacological research today (statins, cyclooxygenase inhibitors, endurobol in doping). Thus, the mission of the LIFS is to provide the bioinformatic framework to understand lipids in context and create an integrative systems biology view for lipid research.