LCE00000015 - Glycerophospholipid remodeling is critical for orthoflavivirus infection

Title	Glycerophospholipid remodeling is critical for orthoflavivirus infection
Contacts	Eva Herker, This email address is being protected from spambots. You need JavaScript enabled to view it. Institute of Virology, Philipps-University Marburg, Marburg, Germany Dominik Schwudke, This email address is being protected from spambots. You need JavaScript enabled to view it. Division of Bioanalytical Chemistry, Research Center Borstel - Leibniz Lung Center, Borstel, Germany German Center for Infection Research, Thematic Translational Unit Tuberculosis, Partner Site Hamburg-Lübeck-Borstel-Riems, Borstel, Germany German Center for Lung Research (DZL), Airway Research Center North (ARCN), Research Center Borstel - Leibniz Lung Center, Borstel, Germany
Publication	Peer reviewed publication: Hehner, J., Schneider, L., Woitalla, A. et al. Glycerophospholipid remodeling is critical for orthoflavivirus infection. Nat Commun 15, 8683 (2024). https://www.nature.com/articles/s41467-024-52979-y Published: 07 October 2024 Preprint: not available
Accession	LCE00000015 (LipidCompass) MTBLS11030: Glycerophospholipid remodeling is critical for orthoflavivirus infection (MetaboLights)
Status	In curation (Links / accessions may not work yet)
Organism	Human hepatoma HuH-7 cell line (BTO:0001950) infected with Zika Virus (NCBITaxon:64320), West Nile Virus (NCBITaxon:11082), Tick-borne Encephalitis Virus (NCBITaxon:11084), Dengue Virus (NCBITaxon:12637), Yellow Fever Virus (NCBITaxon:11089)
Supplementary Material	Manuscript Supplements: Supplementary Table S1 - Lipid quantities after viral infection at different timepoints (322 lipids, 16 classes): 240123_Table_S1.xlsx Supplementary Table S2 - FA composition of membrane and storage lipids species changes following infection for PC, PE, PS, and TAG: 240123_Table_S2.xlsx Lipidomics Reporting Checklist: Lipidomics Reporting Checklist PDF Lipidomics Results: LipidXplorer Positive ion mode analysis settings: 211129_Virus_Eva_Herker-project.lxp LipidXplorer Positive ion mode report (w/ MFQL): 211129_Virus_Eva_Herker_pos-report_screen.html LipidXplorer Positive ion mode analysis (TAG FA Content) settings: 220719_TAG_FAs.lxp LipidXplorer Positive ion mode report (TAG FA Content, w/ MFQL): 211129_Virus_Eva_Herker_pos-report.html LipidXplorer Negative ion mode analysis settings: 211129_Virus_Eva_Herker-project_neg.lxp Cholesterol determination after acetylation positive ion mode report (w/ MFQL): 210820_Virus_EH_Batch1_Batch2_Batch3_Chol-report.html Cholesterol determination after acetylation negative ion mode report (w/ MFQL): 211022_Virus_EH_Batch1_Batch2_Batch3_neg-report.html
Created	December 12th, 2023
Last Updated	February 25th, 2025
Curators	Nils Hoffmann