Even with lipid content of over 10% in the human body, lipids were not the central scientific focus during the last decade. However, more and more evidence proves that non-genetically determined molecules such as metabolites and lipids play a critical role in cellular regulation. Today, it is evident that lipids are not only crucial for energy homeostasis and as an environmental-cellular barrier but also that they represent a central part of our signal transduction machinery. Thus, the mission of the LIFS is to provide the bioinformatic framework to understand lipids in context and create an integrative systems biology view for lipid research.